hidden pixel

4-dimethylaminophenol Information

4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1]

It works by generating methemoglobin. [2]

This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.

In an animal model, it has shown effectiveness when given intramuscularly.[3]

See also

References

  1. ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. doi:10.1046/j.1365-2044.2000.01628.x. PMID 11121929. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0003-2409&date=2000&volume=55&issue=12&spage=1189.
  2. ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097.
  3. ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842.
Antidotes (V03AB)
Nervous system
Nerve agent / Organophosphate poisoning Atropine# • Biperiden • Diazepam# • Oximes (Pralidoxime, Obidoxime) • see also Cholinesterase
Opioid overdose Diprenorphine • Doxapram • Nalorphine • Naloxone# • Naltrexone • Nalmefene
Barbiturate overdose Bemegride • Ethamivan
Benzodiazepine overdose Cyprodenate • Flumazenil
GHB overdose Physostigmine • SCH-50911
Reversal of neuromuscular blockade Sugammadex
Cardiovascular
Heparin Protamine#
Digoxin toxicity Digoxin Immune Fab
Beta blocker Glucagon
Other
Methanol / Ethylene glycol poisoning Ethanol • Fomepizole
Paracetamol toxicity (Acetaminophen) Acetylcysteine# • Glutathione • Methionine#
Arsenic poisoning Dimercaprol# • Succimer
Cyanide poisoning nitrite (Amyl nitrite, Sodium nitrite#) • Sodium thiosulfate# • 4-Dimethylaminophenol • Hydroxocobalamin
Toxic metals (cadmium, mercury, lead, thallium) Edetates • Dimercaprol# • Prussian blue#
Hydrofluoric acid Calcium gluconate#
Other Prednisolone/promethazine • oxidizing agent (potassium permanganate) • iodine-131 (Potassium iodide) • Methylthioninium chloride#
Emetic Ipecacuanha (Syrup of ipecac) • Copper sulfate

: TOX

/

Categories:

 

The above information uses material from Wikipedia and is licensed under the GNU Free Documentation License.
Some facts may not have been fully verified for accuracy. [Disclaimers]
This page was last archived by our server on Sun Feb 5 16:10:58 2012.
Displaying this page or its contents does not use any Wikimedia Foundation's resources.
The owners of this site proudly support the Wikimedia Foundation.

More Information Results for "4-dimethylaminophenol"
[Hide]▼
'4-dimethylaminophenol' Images
[Hide]▲